Robustness Into Advanced Age of Atopy-Specific Mechanisms in Atopy-Prone Families

Molecular mechanisms of atopy.

Production of specific immunoglobulin (Ig)E is the characteristic abnormality of atopy. IgE is produced by B lymphocytes under the influence of interleukin (IL)4 and IL-13. IgE binds to high-affinity IgE receptors (Fc«RI) on mast cells to induce degranulation and mediator synthesis. IL-4 enhances the activation of Fc«RI to augment the production of cytokines and lipid mediators. These receptors...

Specific IgE Assay for Respiratory Allergens in Patients with Atopy in Ahvaz, Iran

Atopy in children of families with an anthroposophic lifestyle.

BACKGROUND Increased prevalence of atopic disorders in children may be associated with changes in types of childhood infections, vaccination programmes, and intestinal microflora. People who follow an anthroposophic way of life use antibiotics restrictively, have few vaccinations, and their diet usually contains live lactobacilli, which may affect the intestinal microflora. We aimed to study th...

Beyond Atopy

The University of Manchester, Manchester Academic Health Science Centre, NIHR Translational Research Facility in Respiratory Medicine, University Hospital of South Manchester NHS Foundation Trust, Manchester, United Kingdom; Stochastic Systems Group, Laboratory for Information and Decision Systems, Massachusetts Institute of Technology, Cambridge, Massachusetts; Microsoft Research Cambridge, Ca...

Asthma and atopy

F emale sex hormones seem to have something to do with asthma and allergy. You might think this is a bit vague, but the research on this so far doesn’t merit anything stronger. Women of reproductive age are more likely to be admitted to hospital for asthma than men. Intrigued by this, people have studied the link between asthma or allergy and markers of female sex hormone levels—for example, ti...